Humans’ DNA is 99.9% the same — but we’re also surprisingly similar to a bunch of other living things Lydia Ramsey Science May. 6, 2016, 10:03 PM When it comes to protein-encoding genes, mice are 85% similar to humans. For non-coding genes, it’s only about 50%. The National Human Genome Research Institute attributes this similarity to a shared ancestor about 80 million years ago. Share Tagged In BooksEntrepreneurscienceTech Discuss Comments are closed.